The Ectocellect human cell surface receptor discovery platform
Discover extracellular protein interactions and characterize proteins for drug discovery in a scalable, cost-effective format
Our Technology
Our technology consists of a high-quality genome-scale human protein array containing functional receptor ectodomains. Every receptor design is manually-optimized, allowing us to recreate its structural architecture including type I and type II membrane proteins, and dimeric/trimeric receptor complexes.
Every protein is individually expressed, purified, and quality checked, alongside decades of characterization work to ensure we can quantify even some of the most difficult-to-detect weak interactions. We can then re-create arrays of surface proteins immobilized in arrays that mimic their natural orientation.
Applications
- Discovering interactions of proteins, cells, or other molecules across the arrays of receptors
- Specificity testing to find off-targets for therapeutics, including monoclonal antibodies, chimeric molecules, CARs, nanobodies, etc.
- Validation of AI-designed binders
- Identifying the targets of antibodies of unknown binding specificity
- Discovering targets of idiopathic antibody-based autoimmunity
- Identifying the binding targets of ‘orphan’ ligands
Boost your research using the Ectocellect receptor array for :
Cost effectively test binding specificity of antibodies or AI-designed binders.
